Milestones
The first successful animal embryo transfer was in Vietnam (1978).The first successful in vitro fertilization and embryo sexing in animals in Vietnam (2002,2003). Application of somatic cell nuclear transfer for conservation of genetic resources of endangered wild species since 2000.
STEM CELL TECHNOLOGY-BIOMEDICINE
CRYOBIOLOGY- CELL & EMBRYO PRESERVATION
The first world successful embryo cryopreservation by rapid freezing after partial dehydration at room temperature (1983). The first baby from cryopreservation semen in Vietnam (1999)
ADVANCED REPRODUCTIVE BIOTECHNOLOGY
DIGITAL INTEGRATION
Stem cell isolation, characterization, expantion and standardization. Production of animal embryonic stem cells, human mensenchymal stem cells; production of cardiac, neural stem cells by in vitro differentiation (2002, 2007. 2015).
Science & Technology Potentials
IInterdisciplinary integration of informatics and biotechnology for developing a new strategy of in situ-ex situ combined biodiversity conservation, developing a model of digital farming, upgrading the level of automated real-time monitoring for cell cryobanking, cell culture and therapy.
Technological History & Achievements
1978-First sussesful embryo transfer
1983-First world successful embryo rapid freezing
2000-First SCNT cloning embryo vitrification
1986-1996- Estrus synchronization, superovulation, fresh & frozen embryo transfer in buffalo, cattle, goat
From 2006- cGMP manufactoring platform for Human stem cells cryobanking, expansion and differentiation
1992-2003- In vitro fertilization embryo production, sexing & intercontinental embryo transfer
Since 1998-Sample cryobanking & interspecies SCNT cloning of wild endangered species gaur cattle, minipig Ban, monkey,...
SABC experts and collaborators have chaired and participated in many national and international projects working on the application of technological innovations for improving biodiversity conservation, livestock development and for biomedicine.
Research projects
National projects R&D in Embryo Biotechnology (470107, 1980-1985; 52D-0113,1986-1990;KC-08-16); Vietnam National Foundation for Science and Technology Development (NAFOSTED) project on somatic cloning;
project of cooperation with AIRE Development and INRA French on cryobiology and embryo preservation, embryo transfer; project for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN), Japan for somatic cloning and vitrification cryopreservation; Vietnam_Italy Project on development of reproductive technology in buffalo; Vietnam-USA project on in vitro fertilization sexing and intercontionental embryo transfer.
MOST Project ĐTĐL 2007/03 for differentiation of human umbilical cord matrix stem cell into neural and cardiac progenitor cells; Viet-Thailand project on induction of corneal epithelial cells;
https://rep.bioscientifica.com/view/journals/rep/71/2/jrf_71_2_032.xml?rskey=b49amE&result=4; https://pubmed.ncbi.nlm.nih.gov/16725971/
DOI: 10.1016/0093-691x(84)90459-x
https://pubmed.ncbi.nlm.nih.gov/10898213/
https://www.publish.csiro.au/rd/RDv19n1Ab93
https://pubmed.ncbi.nlm.nih.gov/25474756/
Transfer technology and Development project
Project supported by AIRE-Developpement (International Agency for Research and Study for Development, French), INRA French, Bomed-USA for implementation of embryo biotechnology in domestic animal breeding.
Project Biodiva Supported by FSP (Fonds de solidarité prioritaire), FFEM (Fonds français pour l'environnement mondial), CIRAT Centre de Coopération Internationale en Recherche Agronomique pour le Développement) and INRA for "Inventory, characterization and promotion of domestic animal biodiversity and wilderness of the Annamitic Cordillera in Vietnam, for conservation and sustainable development", improvement of somatic Cloning of wild Saola and Gaur, cryobank management and development of in situ - ex situ links.
JSPS-Japan-VAST Vietnam Project for application vitro production, manipulation and preservation of porcine embryos of Vietnam's native pig breeds for the conservation of biodiversity in pigs.
Project 01C-05/04-2016-3, supported by HanoiDOST. Main objective: Developing technique of reproductive management for improving rabbit production.
https://pigtrop.cirad.fr/content/download/2581/13171/file;https://www.publish.csiro.au/RD/RDv16n1Ab259;https://www.publish.csiro.au/rd/ExportCitation/rdv17n2ab56; https://www.publish.csiro.au/RD/RDv16n1Ab259)
https://123dok.net/article/la-production-scientifique-et bibliographique.qvl9g9ng;
https://agris.fao.org/agris-search/search.do?recordID=FR2013104863