R&D OUTCOMES
iSCNT has been developed in cooperation with Japanese experts for technology transfer since 1998. interspecific somatic cell nuclear transfer was applied for conservation of genetic resources of endangered wild species in wild cattle, monkey, native pig, Saola Nghetinhensis Pseydoryx..
iSCNT CLONING
CELL & EMBRYO CRYOBANKING
Applying the laws of anhydrobiosis and ontogenesis to cryopreservation research, SABC experts have successfully developed a method to preserve animal embryos at liquid nitrogen minus 196 °C by rapid freezing after partial dehydration for the first time in the world. (1983). The first baby from cryopreserved semen in Vietnam was in 1999. The first successful vitrification of cloning embryos was in 2000, and vialable fish embryo in 2010..
ADVANCED REPRODUCTIVE
BIOTECHNOLOGY
DIGITAL INTEGRATION
Stem cell isolation, characterization, expantion and standardization. Production of animal embryonic stem cells, human mensenchymal stem cells; production of cardiac, neural stem cells by in vitro differentiation (2002, 2007. 2015).
Science & Technology Potentials
Interdisciplinary integration of informatics and biotechnology for developing a new strategy of in situ-ex situ combined biodiversity conservation, developing a model of digital farming, upgrading the level of automated real-time monitoring for cell cryobanking, cell culture and therapy.
Starting with the first successful embryo transfer experiment on rabbits in 1978, through technology transfer cooperation activities with advanced reproductive biotechnology centers in France, the US, and Japan, ASBC's experts have conducted innovation research to adapt the technology to local tropical non-standardized livestock farming conditions, creating optimal results in ovarian activity management, embryo transfer, in vitro fertilization in differient breeding species.
The first successful bovine embryo transfer was in Vietnam (1986). The first successful in vitro fertilization and transfer embryo sexing was in 2002.
STEM CELL TECHNOLOGY-BIOMEDICINE
SOMATIC CELL NUCLEAR TRANSFER REPROGRAMMING
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Milestones Achievements
SABC is initiated and led by experienced experts in the field of modern embryonic biotechnology, updating the world's technology progress following embryo transfer, embryo cryopreservation, in vitro embryo production, and somatic cloning in the 80s and 90s of the twentieth century to today’s cutting-edge stem cell and gene-based innovation
1978–1986 | Embryo Biotechnology Pioneer
Achieved the first successful embryo transfer in an experimental animal (1978) and a domestic animal (1986), establishing a foundation for advanced reproductive biotechnology.
1983 | Breakthrough in Cryobiology
Developed the world's first successful rapid embryo freezing technology following room-temperature dehydration, marking a major milestone in cryopreservation science.
1998–2000 | Somatic Cloning & Cell Reprogramming
Pioneered interspecies somatic cell nuclear transfer (SCNT) in endangered wild animal species, advancing cloning and conservation biotechnology.
1999 | Human Reproductive Medicine
Initiated the first successful semen cryobanking program and its clinical application in infertility treatment.
2000 | Advanced Embryo Cryopreservation
Achieved the first successful vitrification of somatic cloning embryos, expanding the potential of cloning and regenerative technologies.
2002 | In Vitro Embryo Production Innovation
Successfully produced, sexed, and transferred in vitro fertilized embryos, representing a significant advancement in reproductive biotechnology.
2008–2010 | Stem Cell Biotechnology Development
Established pioneering capabilities in mesenchymal stem cell (MSC) cryopreservation and differentiation, supporting the emergence of regenerative medicine applications.
2010–Present | Clinical Translation & Cell Banking
Implemented stem cell banking technologies and clinical applications in collaboration with leading hematology, obstetrics, blood transfusion, and oncology hospitals, creating a platform for next-generation Cell & Gene Therapy (CGT) innovations.
SABC experts and collaborators have chaired and participated in many national and international projects working on the application of technological innovations for improving biodiversity conservation, livestock development and for biomedicine.
Research projects
National projects R&D in Embryo Biotechnology (470107, 1980-1985; 52D-0113,1986-1990;KC-08-16); Vietnam National Foundation for Science and Technology Development (NAFOSTED) project on somatic cloning;
project of cooperation with AIRE Development and INRA French on cryobiology and embryo preservation, embryo transfer; project for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN), Japan for somatic cloning and vitrification cryopreservation; Vietnam_Italy Project on development of reproductive technology in buffalo; Vietnam-USA project on in vitro fertilization sexing and intercontionental embryo transfer.
MOST Project ĐTĐL 2007/03 for differentiation of human umbilical cord matrix stem cell into neural and cardiac progenitor cells; Viet-Thailand project on induction of corneal epithelial cells;
https://rep.bioscientifica.com/view/journals/rep/71/2/jrf_71_2_032.xml?rskey=b49amE&result=4; https://pubmed.ncbi.nlm.nih.gov/16725971/
DOI: 10.1016/0093-691x(84)90459-x
https://pubmed.ncbi.nlm.nih.gov/10898213/
https://www.publish.csiro.au/rd/RDv19n1Ab93
https://pubmed.ncbi.nlm.nih.gov/25474756/
Transfer technology and Development project
Project supported by AIRE-Developpement (International Agency for Research and Study for Development, French), INRA French, Bomed-USA for implementation of embryo biotechnology in domestic animal breeding.
Project Biodiva Supported by FSP (Fonds de solidarité prioritaire), FFEM (Fonds français pour l'environnement mondial), CIRAT Centre de Coopération Internationale en Recherche Agronomique pour le Développement) and INRA for "Inventory, characterization and promotion of domestic animal biodiversity and wilderness of the Annamitic Cordillera in Vietnam, for conservation and sustainable development", improvement of somatic Cloning of wild Saola and Gaur, cryobank management and development of in situ - ex situ links.
JSPS-Japan-VAST Vietnam Project for application vitro production, manipulation and preservation of porcine embryos of Vietnam's native pig breeds for the conservation of biodiversity in pigs.
Project 01C-05/04-2016-3, supported by HanoiDOST. Main objective: Developing technique of reproductive management for improving rabbit production.
https://pigtrop.cirad.fr/content/download/2581/13171/file;https://www.publish.csiro.au/RD/RDv16n1Ab259;https://www.publish.csiro.au/rd/ExportCitation/rdv17n2ab56; https://www.publish.csiro.au/RD/RDv16n1Ab259)
https://123dok.net/article/la-production-scientifique-et bibliographique.qvl9g9ng;
https://agris.fao.org/agris-search/search.do?recordID=FR2013104863